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Subha Basu, Ph.D
Training:
2001 -Ph.D. - Microbiology and Immunology, Downstate
Medical Center
Brooklyn, NY State University of New York
1994 BA - Biochemistry and Molecular Biology, Berkeley,
CA University of California
Research Interest:
Batten’s disease, or infantile neural ceroid lipofuscinosis (INCL),
is a degenerative childhood disorder whose symptoms include severe neurodegeneration,
progressive blindness and seizures. Palmitoyl-protein thioesterase 1
(PPT1 or CLN1) is a lysosomal protein whose deficiency/mutation is genetically
attributed to INCL. PPT1 removes fatty acyl side chains from cysteine
residues of proteins in lysosomes. The transgenic knockout mouse PPT1-/-
recapitulates human disease and shows neuronal loss in the hippocampus
and cerebellum as well as accumulation of autofluorescent storage material
in these areas. |
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Contact me:
Lab:P222, MSLS building
498-8112
E-mail:sbasu@stanford.edu |
Recent Publication:
Moskowitz SI, Basu SB, and Bergold PJ. Chronic and cyclical neuronal loss
in hippocampal slice cultures following transient inhibition of the type
1 isoform of superoxide dismutase. Brain Research, Sept.21, 913(2):207-19 |
